Prescription Drug Induced Type 2 Diabetes
I had a heart valve replaced and bypass surgery on Dec 18, 2018. After that, I was put on a high dose of a statin, metoprolol, and because my T4 was a bit low and my TSH a bit high I was also put on levothyroxine. My blood sugar was fine before the surgery but has steadily increased over the last 3 years and I am now diagnosed with type 2 diabetes.
Insulin resistance and levothyroxine
It is pretty well known that statins cause insulin resistance and type 2 diabetes but not so well know that metoprolol deteriorates insulin-stimulated endothelial function (Kveiborg et al., Cardiovascular Diabetology 2010 9:21). It is nearly impossible to find publications on the possibility of levothyroxine being a cause of type 2 diabetes even though it is known that thyroid hormones affect blood sugar levels. There is very little research out there that documents the effect of increased levels of blood sugar and insulin resistance as a direct effect of levothyroxine consumption even though thyroid hormones are known to increase glucose production in the liver and increase insulin resistance.
Lacking information by doctors and research
I feel as if I was doomed to develop type 2 diabetes by taking these 3 medications. I was never informed by any one of the effects these medications would have on my blood sugar and my first endocrinologist did not even check my blood sugar levels. According to several webpages, levothyroxine is the number one most prescribed drug in the USA; the occurrence of type 2 diabetes is bordering on epidemic and yet there is no research documenting the effect of levothyroxine and the development of type 2 diabetes.
What aspect of diabetes management do you struggle with most?