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Mounjaro Side Effects: How Have Others Dealt With It?

I started Mounjaro 2.5 mg in August. Felt much better fairly quickly, lost a ton of weight. Noticed some stomach symptoms, but nothing that was a problem. Increased to 5mg beginning of November. I have since developed a pretty persistent case of constipation that started early this last week (week of 11/13). I’ve added laxatives to my daily routine, but have yet to experience full relief. Literature suggests this maybe temporary, but my poor intestines aren’t feeling real optimistic at the moment. I wanted to hear other’s experience with similar symptoms, and if they were able to resolve them, and how.

  1. Hi . I don't have experience with Mounjaro, but I know that constipation can be a serious side effect of some diabetes medications. If this doesn't resolve soon, you might want to talk with your doctor about trying something new. Are you drinking lots of water? Laxatives can help get things moving, but they can also be very dehydrating. I hope others chime in with their experiences. While you wait for more responses, here is an article about diabetes and gastrointestinal issues that might interest you: I hope it helps. Best wishes. - Lori (Team Member)

    1. We appreciate you sharing. May I ask, have you tried implementing more fiber into your diet instead of laxatives? I take fiber daily just make sure I can cleanse and clear the system. -B. Keith Crear III (Team Member)

      1. Hello, I am a newbie to this forum and was searching it for mounjaro threads. Hopefully, your issue has been resolved. But I do have a question for you. My doctor recently suggested strongly that I should start this drug, but I had some concerns before I did. Could I reach out to you and pick your brain on using this drug? Thank you!

        1. You must be excited to see that new A1C score when you do get tested. I hope you will keep us posted. How wonderful that the side effects have subsided and you've found a dose that works for you. Thirty pounds! Congratulations! - Lori (Team Member)

        2. Hi I totally understand your concern, but we have lots of articles about traveling with type 2 diabetes that might be helpful. Here is an article with some general travel tips: Here is one air travel: If you talk with the airline first and get the proper documentation from your doctor, you shouldn't have issues keeping your medication cold or packing it in your carry-on. Eating food you are not accustomed to can be tough, but I think you will find it's not that different from eating out in the U.S. You are always safest eating food you recognize, like meats and sides without sauces. If you have a cell phone plan while you are abroad, you can look up items on the menu to get a general idea of the carb content. Lauren gave you some great advice about testing foods ahead of your trip. You could also research some dishes you really want to try to see whether they are diabetes friendly. I hope that helps and that you adjust well to Mounjaro well ahead of the trip if you decide to take it. Fingers crossed for no side effects! Wishing you the best. - Lori (Team Member)

      2. I am also on Monjauro but had constipation problems before I had started. My specialist said-Don’t take any treatments except a dose of Miralax every day. All other medicines can cause permanent digestive issues. I have also made sure I’ve increased my fiber intact and “treat” myself to 4 prunes per day. Not the best treatment but it’s been doable.

        1. I took a combination of polyethylene glycol and docusate sodium for a couple weeks, and that helped. My endocrinologist recommended me not take stimulant laxatives if I could help it. I took sennosides 8.6 mg for maybe four or five days, but I was able to stop using it after that. I was eventually able to wean off the pg first, and then I stopped the docusate about 3 weeks later. I do eat prunes regularly. I already liked them anyway, so I just started eating more and more often. Fortunately eating them is not having an impact on my glucose levels.

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