I've been diabetic for 10 years. At first Metformin didn't give me problems, but now it's become a nightmare. Dr. tried introducing me to other meds but still the same problems with other meds. She wants me to try a different " catagory" of meds but they can cause yeast infections. I'm trying to work with my diet and cutting back o n Metformin (while still taking glimepiride no bad reactions). Wish I could take more glimepiride but maxed out on that. I ride a Stationary bike 45 minutes a day too, but glucose is still 200 in the morning. It's all over the map in the morning! Have been having GI problems for a month!