Meglitinide Derivatives

What are meglitinide derivatives?

Meglitinide derivatives are a class of medications that can be used to treat people with type 2 diabetes.

Meglitinide derivatives work by stimulating the pancreatic beta cells to release insulin, and this additional insulin can help with blood sugar control in people with type 2 diabetes. Meglitinides action on the pancreatic beta cells is dependent on glucose, so they must be taken before meals to get the most benefit. Also, for this type of medication to help, the person must still have functioning pancreatic beta cells.

Meglitinide derivatives medications are sold under some of the following brand names:

What is Prandin (repaglinide)?

Prandin, in which repaglinide is the active ingredient, is a type of meglitinide medication that can help adults with type 2 diabetes to control their blood sugar levels. Prandin works by triggering the release of insulin by the pancreatic beta cells in the pancreas. This can help to lower blood sugar levels, especially blood sugar that is higher after eating. Prandin should be used in combination with a healthy diet and regular exercise.

The AACE guidelines recommend that Prandin (repaglinide) is suitable to use with caution for certain people with type 2 diabetes who:

  • Have tried unsuccessfully to manage their blood sugar with lifestyle therapy (healthy diet, exercise, and weight loss) and need to try a diabetes medication.
  • Have tried to control their blood sugar with one or more other diabetes medications for several months, but now need to add on another medication.

Prandin is taken by mouth in tablet form. Most people take Prandin within half an hour before each main meal, but your healthcare provider will let you know exactly how you should take the medication. Prandin should not be taken before a skipped meal as this can cause hypoglycemia (low blood sugar), talk to your healthcare provider about this.

Some of the most common side effects caused by treatment with Prandin include:

  • hypoglycemia
  • Runny or stuffy nose
  • Headache
  • Joint pain
  • Nausea
  • Diarrhea
  • Back pain

Some people may develop serious cardiac side effects after taking Prandin, talk to your healthcare provider about these.

Do not take Prandin (repaglinide) if you are allergic to it or any of the ingredients found in it. Also talk to your healthcare provider about potential drug interactions before starting therapy or if you experience any side effects.

What is Starlix (nateglinide)?

Starlix is a medication used to help control blood sugar in adults with type 2 diabetes when combined with a healthy diet and regular exercise. Nateglinide, the active ingredient in Starlix, is a meglitinide derivative medication that works by stimulating the pancreatic beta cells to release insulin.

The AACE guidelines recommend that Starlix(nateglinide) is suitable to use with caution for certain people with type 2 diabetes who:

  • Have tried unsuccessfully to manage their blood sugar with lifestyle therapy (healthy diet, exercise, and weight loss) and need to try a diabetes medication.
  • Have tried to control their blood sugar with one or more other diabetes medications for several months, but now need to add on another medication.

Starlix is usually taken by mouth in a tablet within 30 minutes before each main meal. Be sure to take Starlix exactly as prescribed by your healthcare provider. Starlix should not be taken before a skipped meal as this can cause hypoglycemia (low blood sugar), talk to your healthcare provider about this.

Some of the most common side effects reported by people who take Starlix are:

Do not take Starlix (nateglinide) if you are allergic to it or any of the ingredients found in it. Also talk to your healthcare provider about potential drug interactions before starting therapy or if you experience any side effects.

Written by: Anna Nicholson | Last reviewed: April 2017.
View References